Principal Investigator

 

Dr. Jie Zheng

 

Research Associate Professor

 

Dr. Mengxiao Yu

 

Staffs

 

Dr. Xuhui Ning

 

Dr. Yingyu Huang

 

Ms. Xingxing Zhao

 

Dr. Greg Zhang

 

PhD Candidate

 

Ms. Samira Ahrari

 

Graduate Students

 

Ms. Shafie, Arefeh

 

Mr. Wei Xiao

 

Undergraduate Students

 

Mr. Dylan Sreshta

 

Ms. Qian (Emily) Xu

 

Ms. Lily Nguyen

 

Mr. Danny Habbas

 

Visisting Professor

 

Former Group Members

 

Dr. Jinbin Liu (Postdoc)

Dr. Shengyang Yang (Postdoc)

Dr. Jing Yu (Postdoc)

Dr. Zhanghua Zeng (Postdoc)

Dr. Liang Zhao (Postdoc)

Dr. Juanzhu Yan (Postdoc)

Dr. Shaoheng Tang (Postdoc)

 

Ms. Jennifer Chilek (Graduate)

Dr. Chen Zhou (Graduate)

Dr. Shasha Sun (Graduate)

Dr. Rodrigo Vinluan III (Graduate)

Ms. Jessica Jacobe (Graduate)

Dr. Jing Xu (Graduate)

Dr. Bujie Du (Graduate)

Dr. Xingya Jiang (Graduate)

Dr. Chuanqi Peng (Graduate)

Dr. Qinhan Zhou (Graduate)

Dr. Siqing Li (Graduate)

Mr. Yue Chong (Graduate)

 

Ms. Sheby Alexander (Undergraduate)

Mr. Chris Alameddin (Undergraduate)

Mr. Michael Anyirah (Undergraduate)

Mr. Sishan Chen (Undergraduate) 

Mr. Giovanni Contello (Undergraduate) 

Mr. Andrew Dean (Undergraduate)

Ms. Melissa Gannaway (Undergraduate)

Ms. Julia Hankins (Undergraduate)

Ms. Grace Kong (Undergraduate)

Mr. Stephen McMahon (Undergraduate)

Mr. Husain Mogri (Undergraduate)

Mr. Ali Mozayan (Undergraduate)

Mr. Justin Sullins (Undergraduate)

Mr. Joel Taylor (Undergraduate)

Mr. Jonathan Wang (Undergraduate)

Mr. Greg Zhang (Undergraduate)

Mr. Anthony Dao (Undergraduate)

Ms. Phoebe Carter (Undergraduate)

 

Ms. Chelsea Carson (High School)

Ms. Karen Chen (High School)

Ms. Clare Jensen (High School)

Ms. Rebecca John (High School)

Ms. Amy Xia (High School)

Mr. Robert Yao (High School)

 

 

 

 

 

 

 

  

Mengxiao Yu

 

Research Associate  Professor

 

 

Office: NSERL 2.440

 

E-mail: mxy091000@utdallas.edu

 

Mailing Address:

 

BE26, The University of Texas at Dallas, 800 W Campbell Rd. Richardson, TX 75080
 
 

Education Background

 

Postdoc in Chemistry,  The University of Texas at Dallas, USA, 2009-2014.

 

Ph.D. Laboratory of Advanced Materials, Fudan University, Shanghai, China, 2009.

 

B.S.  Department of Chemistry, Beijing Normal University, Beijing, China, 2004.

Research Area

 

Noninvasive Kidney functional Imaging.

 

Honors and Awards

 

Best Poster in Biomaterials and Tissue, UT Metroplex Day, 2010.

 

Selected Publications

32. X. Y. Jiang, Q. H. Zhou, B. J. Du, Y. Y. Huang, M. X. Yu, Z.K. Chi, W. M. Lee and J. Zheng, “Noninvasive Monitoring of Hepatic Glutathione Depletion through Fluorescence Imaging and Blood Test”, Science Advances, 2021; 7: eabd9847.

 

31. B. J. Du, Y. Chong, X. Y. Jiang, M. X. Yu, U. G. Lo, A. Dang, Y. A. Chen, S. Q. Li, E. Hernandez, J. C. Lin, J. T. Hsieh, J. Zheng*. Renal Secretion Pathway-dependent Efflux Transport Enabled Hyperfluorescence Imaging of Kidney Cancer. Angew. Chem. Int. Ed. 2021, 60(1): 351–359. Highlighted as Very important paper

 

30.C. Q. Peng, M. X. Yu, J. Zheng*. In Situ Ligand-Directed Growth of Gold Nanoparticles in Biological Tissues, Nano Letters 20, 1378-1382 (2020).

 

29. Leong, H. S… M. X. Yu, … C. Pastore*. "On the issue of transparency and reproducibility in nanomedicine", Nature Nanotech, 2019, 14, 629-635.

 

28. C. Q. Peng, M. X. Yu, J. T. Hsieh, P. Kapur, J. Zheng*. Correlating Anticancer Drug Delivery Efficiency with Vascular Permeability of Renal Clearable Versus Non-renal Clearable Nanocarriers. Angew. Chem. Int. Ed. 58, 12076-12080 (2019).

 

27. C. Q. Peng, J. Xu, M. X. Yu, X. H. Ning, Y. Y. Huang, B. J. Du, E. Hernandez, P. Kapur, J. T. Hsieh, J. Zheng. Tuning in vivo transport of anticancer drugs with renal‐clearable gold nanoparticles. Angew. Chem. Int. Ed. DOI: 10.1002/anie.201903256 (2019).

 

26. M. X. Yu, J. Xu, J. Zheng. Renal Clearable Luminescent Gold Nanoparticles: From the Bench to the Clinics. Angew. Chem. Int. Ed. 58, 4112 (2019).

 

25. M. X. Yu. How nanotechnology imaging can be used in kidney disease: An interview with Dr Mengxiao Yu. Nanomedicine (Lond). 13, 3071 (2018).

 

24. B. J. Du, M. X. Yu, J. Zheng. Transport and interactions of nanoparticles in the kidneys. Nature Reviews Materials, 3, 358 (2018).
 

23. Xu, J., Yu, M., Peng, C., Carter, P., Tian, J., Ning, X., Zhou, Q., Tu Qiu., Zhang G., Dao A., Jiang X., Kapur, P., Hsieh, J., Zhao, X., Liu, P., Zheng, J., “Dose Dependencies and Biocompatibility of Renal Clearable Gold Nanoparticles: From Mice to Non-human Primates.” Angew. Chem. Int. Ed. 2018, 57, 266 –271.

 

22. J. Xu, M. Yu, P. Carter A, E. Hernandez, A. Dang, P. Kapur, J. T. Hsieh, J. Zheng. "In Vivo X-ray Imaging of Transport of Renal Clearable Gold Nanoparticles in the Kidneys", Angew. Chem. Int. Ed., 2017, DOI: 10.1002/anie.201707819 (online) (Highlighted as VIP)

 

21. Bujie Du, Xingya Jiang, Anindita Das, Qinhan Zhou, Mengxiao Yu, Rongchao Jin, Jie Zheng, "Glomerular barrier be haves as an atomically precise bandpass filter in a sub-nanometre regime" Nature nanotechnology, 2017 DOI: 10.1038/NNANO.2017.170 (online) 

 

20. Yu, M., Zhou, C., Liu, L., Zhang, S., Sun, S., Hankins, J.D., Sun, X. and Zheng, J., 2017. "Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects."Angew. Chem. Int. Ed., 56, pp.4314-4319.

19. Jing Xu, Chuanqi Peng, Mengxiao Yu and Jie Zheng. "Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications." WIREs Nanomed Nanobiotechnol 2017. doi: 10.1002/wnan.1453)

 

18. Chuanqi Peng, Xiaofei Gao, Jing Xu, Bujie Du, Xuhui Ning, Shaoheng Tang, Robert M. Bachoo, Mengxiao Yu, Woo Ping Ge and Jie Zheng "Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles." Nano Research, 2017 4, 1366-1376

 

17. Shaoheng Tang, Chuanqi Peng, Jing Xu, Bujie Du, Qinxiao Wang, Rodrigo D. Vinluan, Mengxiao Yu, Moon J. Kim and Jie Zheng. "Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density." Angew. Chem. Int. Ed., 2016, 55, 16039-16043

 

16. J.B. Liu, P.N. Duchesne, M.X. Yu, X.Y. Jiang, X.H. Ning, P. Zhang, J. Zheng. “Luminescent Gold Nanoparticles with Size-independent Emissions”, Angew. Chem. Int. Ed., 2016. 55, 8894-8898 

 

15. M. X. Yu, J. C. Zhou, B. J. Du, X. H. Ning, C. Authement, L. Gandee, P. Kapur, J. T. Hsieh, J. Zheng. “Noninvasive Staging of Kidney Dysfunction Enabled by Renal Clearable Luminescent Gold Nanoparticles”, Angew. Chem. Int. Ed., 55, 2787-2791 (2016) (Highlighted as VIP).

14.M. X. Yu, J. B. Liu, X. H. Ning, J. Zheng*. “High-contrast Noninvasive Imaging of Kidney Clearance Kinetics Enabled by Renal Clearable Nanofluorophores”. Angew. Chem. Int. Ed. 54, 15434-15438 (2015).

13. M. X. Yu, J. Zheng*. “Clearance Pathways and Tumor Targeting of Imaging Nanoparticles”. ACS Nano, 2015, 9, 6655–6674 (2015) (Invited review article, Highlighted as one of the "top 5 most read articles" of ACS Nano in July 2015).

 

12. R. D. Vinluan III, M. X. Yu, M. Gannaway, J. Sullins, J. Xu, Jie Zheng*. “Labeling Monomeric Insulin with Renal-Clearable Luminescent Gold Nanoparticles”. Bioconjugate Chem., DOI: 10.1021/acs.bioconjchem.5b00490 (2015).

11. J. B. Liu, M. X. Yu, C. Zhou, J. Zheng*. "Renal Clearable Inorganic Nanoparticles: A New Frontier of Bionanotechnology". Mater. Today 16, 477-486 (2013).

 

10. J.B. Liu, M.X. Yu, X. Ning, C. Zhou, S.Y. Yang, and J. Zheng*, "PEGylation and Zwitterionization: Pros and Cons in Renal Clearance and Tumor Targeting of Near-IR-Emitting Gold Nanoparticles", Angew. Chem. Int. Ed. 52, 12572-12576 (2013) (Highlighted as VIP)

 

9. J. Liu, M. Yu, C. Zhou, S. Yang, X. Ning, and J. Zheng, “Passive Tumor Targeting of Renal Clearable Luminescent Gold Nanoparticles: Long Tumor Retention and Fast Normal Tissue Clearance”, J. Am. Chem. Soc., 2013, 135, 4978-4981 (2013).

 

8. J. Zheng*, C. Zhou, M. X. Yu, J. B. Liu. "Different sized luminescent gold nanoparticles". Nanoscale 4, 4073-4083 (2012) (Highlighted as one of the "top 10 most accessed articles" of Nanoscale in June and July 2012).

 

7. M. Yu,† C. Zhou,† J. Liu, J. D. Hankins, J. Zheng, “Luminescent Gold Nanoparticles with pH De-pendent Membrane Adsorption”, J. Am. Chem. Soc., 133, 11014-11017 (2011).

 

6. C. Y. Li, M. X. Yu, Y. Sun, Y. Q. Wu, C. H. Huang, F. Y. Li*. "A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells". J. Am. Chem. Soc. 133, 11231-11239 (2011) (Highlighted by Chemical and Engineering News).

5. C. Zhou, C. Sun, M. X. Yu, Y. P. Qin, J. G. Wang, M. Kim, J. Zheng*. "Luminescent Gold Nanoparticles with Mixed Valence States Generated from Dissociation of Polymeric Au(I) Thiolates". J. Phys. Chem. C 114, 7727-7732 (2010).

4. M.X. Yu, F.Y. Li, Z.G. Chen, H. Hu, C. Zhan, H. Yang, C.H. Huang, “Laser Scanning Up-conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-earth Nanophospors”, Anal. Chem., 81, 930–935 (2009).

3. M.X. Yu, M. Shi, Z.G. Chen, F.Y. Li, X.X. Li, Y.H. Gao, J. Xu, H. Yang, Z.G. Zhou, T. Yi, C.H. Huang, “Highly Sensitive and Fast Responsive Fluorescence Turn-on Chemodosimeter for Cu2+ and its Application in Live Cell Imaging”, Chem. Eur. J., 14, 6892–6900 (2008).

 

2. M.X. Yu, Q. Zhao, L.X. Shi, F.Y. Li, Z.G. Zhou, H. Yang, T. Yi, C.H. Huang, “Cationic Iridium(III) Complexes for Phosphorescence Staining in the Cytoplasm of Living Cells”, Chem. Comm., 2115–2117 (2008).

 

1. M. Zhang, M.X. Yu, F.Y. Li, M.W. Zhu, M.Y. Li, Y.H. Gao, L. Li, Z.Q. Liu, J.P. Zhang, D.Q. Zhang, T. Yi, C.H. Huang, “A Highly Selective Fluorescence Turn-on Sensor for Cysteine/Homocysteine and its Application in Bioimaging”, J. Am. Chem. Soc., 129, 10322–10323 (2007).

[Contact us]
2.440 NSERL Building, The University of Texas at Dallas
Tel: 972-883-5768 (Dr. Zheng), 972-883-5769 (Lab)