University
of
Cognition and Neuroscience Program
School
of Behavioral and Brain Sciences, GR41
Richardson,
TX 75083
(972)883-2339
- Office
(972)883-2376
- Lab
(972)883-2491
- FAX
kilgard@utdallas.edu
http://www.utdallas.edu/~kilgard/
Ph.D., Neuroscience Program, 1998 (download
dissertation)
University of California, San Francisco
B.A. Molecular
and Cell Biology (Biochemistry), Honors Program, 1993 (download honors
thesis)
University of California, Berkeley
Wings for Life ($202,590) Promoting
Recovery from Cervical Spinal Cord Injury by Pairing Rehabilitation with Vagus
Nerve Stimulation, 2016.
International Rett Syndrome Foundation Research
Grant ($150,000), Reversing
speech sound processing deficits in Rett syndrome, 2016.
DARPA ElectRx Research
Grant ($6,400,000), Closed-loop
Neuromodulation to Treat PTSD (co-PI
with Rob Rennaker), 2015
NINDS R01 Research Grant ($1,940,000), Vagus
Nerve Stimulation Paired with Rehabilitative Training to Enhance Plasticity
(co-PI with Rob Rennaker), 2014
NINDS R43 Research Grant ($225,043) A
Novel Adjunct to Physical Training to Improve Motor Recovery Following Stroke
(co-PI with Navzer Engineer), 2013
Michael J. Fox Foundation for Parkinson’s Research
Rapid Response Innovation Award ($75,000), Evaluation
of Targeted Plasticity Therapy as a Treatment for Motor Dysfunction in
Parkinson’s (co-PI with Seth Hays), 2013
NIDCD R01 Research Grant ($1,683,000), Animal
Model of Speech Sound Processing in Autism, 2010
NIDCD R44 Research Grant ($2,113,757), Targeted
Neural Plasticity for the Treatment of Tinnitus (co-PI with Navzer
Engineer), 2010
UT Dallas’ nominee for the Chancellor’s
Entrepreneurship and Innovation Award, 2010
University
of Texas Regents’ Outstanding Teaching Award ($30,000), 2009
NIDCD R43 Research Grant ($585,483), Targeted
Neural Plasticity For The Treatment Of Tinnitus (co-PI with Navzer
Engineer), 2009
Chancellor’s Council
Outstanding Teaching Award ($5,000), 2008
Texas Advanced Research
Program Award ($150,000), Guiding Brain Plasticity via Vagus Nerve
Stimulation, 2007
Honorary Member, Golden Key International Honour Society, 2006
NIDCD Academic Research Enhancement Award
($265,961), Cortical
Plasticity and Processing of Speech Sounds, 2004
John Merck Scholar Finalist ($10,000), 2003
James S. McDonnell Foundation Bridging Brain, Mind,
and Behavior Research Award, Brain
Plasticity and Neuro-Rehabilitation ($446,000), 2002
Teaching Award, UTD School of Behavioral and Brain
Sciences, 2002
Cure Autism Now Foundation: Sensory
Experience, Behavioral Therapy and Neural Plasticity: Implications for
Autism Remediation ($80,000), 2002
Callier Scholar Award ($5,000), 2002
NIDCD Research Grant ($152,765), Cortical
Plasticity and Processing of Complex Stimuli, 2000
NIDCD
National Research Service Award ($70,000), 1998 [not
activated]
Krevans Distinguished
Dissertation Award ($500), UC San Francisco, 1998
National Science Foundation Fellowship ($50,000),
1994
Outstanding Geneticist of the Year, UC Berkeley,
1993
National Merit Scholar
Eagle Scout - BSA
2014-present: Associate Director, Texas Biomedical
Device Center
- Creating new biomedical technology and
therapies
2013-present: Margaret Fonde
Jonnson Professor - UT Dallas
- Directing cortical
plasticity to understand and treat neurological disease
2011-2013:
Full Professor - UT Dallas
- Directing
cortical plasticity to understand and treat neurological disease
2004-2011:
Associate Professor - UT Dallas
- Cortical
plasticity and the neural basis of speech sound processing
1999-2004:
Assistant Professor - UT Dallas
- Investigation
of the principles of cortical plasticity
1998: Post-doctoral Fellow -
UC
- Michael Merzenich, Sooy Professor
- Cortical Representation of Spectrotemporal
Stimuli
1994-1998: Doctoral Research - UC
San Francisco
- Michael Merzenich, Sooy Professor
- Induction of large-scale reorganization of primary auditory cortex
by cholinergic forebrain stimulation
- Psychophysics of directed attention in tactile perception
1992-1993: Undergraduate Thesis -
UC Berkeley
- Barbara Meyer,
Howard Hughes Professor of Genetics
- Characterization of mutations in the synaptic vesicle protein, Rab-3 in
C. elegans
- Cloning of cDNA of the C. elegans
sex-determination gene, SDC-2
1991: Research Assistant -
Baylor College of Medicine
- Ron Davis
- Enhancer trap screen for genes expressed in drosophila mushroom bodies
1990: Research Assistant -
Baylor College of Medicine
- Ajay Rege
- Cloning of a cysteine protease from Schistosomiasis mansoni
1988-1989: Technician - Genosys,
Inc. -
- Polynucleotide synthesis
Targeting
Plasticity with Vagus Nerve Stimulation to Treat Neurological Disease. Hays
SA, Rennaker RL, Kilgard MP. In Changing Brains
- Applying Brain Plasticity to Advance and Recover Human Ability, Progress
in Brain Research, 207:275-99, 2013 (download
file).
Neural
Coding of Speech Sounds. Kilgard M., Engineer C. In: Jaeger D., Jung R.
(Ed.) Encyclopedia of Computational Neuroscience: Springer-Verlag
Berlin Heidelberg, 2013.
Experience-Dependent
Plasticity and the Auditory Cortex. KN Shepard, MP Kilgard, RC Liu, in Neural Correlates of Auditory Cognition,
Springer (Eds. A. Popper, R. Fay, and Y. Cohen), Volume 45, 2013. (download file)
Auditory Environment,
Stress, and Brain Plasticity. Nichols JA, Bose M, Jakkamsetti VP, Kilgard MP,
Atzori M. in The Neurobiology of Stress: an
Evolutionary Approach, Research Signpost, (Eds. F Aboitiz and A Dagnino-Subiabre), 2007.
Cortical Plasticity and
Rehabilitation. Moucha R, Kilgard MP, in Reprogramming
the Brain, Progress in Brain Research,
Elsevier, (Ed. A. Moller), 157:111-122, 2006 (download file).
How Sensory Experience
Shapes Cortical Representations, MP Kilgard, in Neuropsychology
of Memory, Guilford Press (Eds. L.R. Squire and D.L. Schacter), 2002. (download
file)
Articles (86): (Search PubMed or Google Scholar)
Pruitt DT, Schmid AN, Danaphongse TT, Flanagan KE, Morrison RA,
Kilgard MP, Rennaker RL 2nd, Hays SA. Forelimb training drives
transient map reorganization in ipsilateral motor cortex. Behav Brain Res. 313:10-6, 2016.
Hays SA, Ruiz A, Bethea T, Khodaparast N, Carmel JB, Rennaker RL 2nd,
Kilgard MP. Vagus nerve
stimulation during rehabilitative training enhances recovery of forelimb
function after ischemic stroke in aged rats. Neurobiol Aging. 43:111-8, 2016.
Centanni TM,
Booker AB, Chen F, Sloan AM, Carraway RS, Rennaker
RL, LoTurco JJ, Kilgard MP. Knockdown of Dyslexia-Gene Dcdc2
Interferes with Speech Sound Discrimination in Continuous Streams. J Neurosci.
36:4895-906, 2016.
Ganzer PD, Meyers EC,
Sloan AM, Maliakkal R, Ruiz A, Kilgard MP, Robert LR
2nd. Awake behaving
electrophysiological correlates of forelimb hyperreflexia, weakness and
disrupted muscular synchronization following cervical spinal cord injury in the
rat. Behav Brain Res. 307:100-11, 2016.
Meyers E, Sindhurakar A, Choi R, Solorzano R, Martinez T, Sloan A,
Carmel J, Kilgard MP, Rennaker RL 2nd, Hays S. The supination assessment
task: An automated method for quantifying forelimb rotational function in rats.
J Neurosci
Methods. 266:11-20, 2016.
Hulsey, DR, Hays, SA, Khodaparast, N, Ruiz, A,
Das, P, Rennaker, RL, Kilgard, MP. Reorganization of Motor
Cortex by Vagus Nerve Stimulation Requires Cholinergic Innervation. Brain Stimulation. 9:174-81, 2016.
Khodaparast N, Kilgard
MP, Casavant R, Ruiz A, Qureshi I, Ganzer PD, Rennaker RL 2nd, Hays SA. Vagus Nerve Stimulation
During Rehabilitative Training Improves Forelimb Recovery After Chronic
Ischemic Stroke in Rats. Neurorehabil Neural
Repair. 30:676-84, 2016.
An Automated Task for the
Training and Assessment of Distal Forelimb Function in a Mouse Model of
Ischemic Stroke. Becker AM, Meyers E, Sloan A, Rennaker R, Kilgard M,
Goldberg MP. J Neuroscience Methods,
2015.
Cortical Map Plasticity as a
Function of Vagus Nerve Stimulation Intensity. Borland MS, Vrana WA, Moreno
NA, Fogarty EA, Buell EP, Sharma P, Engineer CT, Kilgard MP. Brain Stimulation, 2015.
Degraded neural and
behavioral processing of speech sounds in a rat model of Rett syndrome.
Engineer CT, Rahebi KC, Borland MS, Buell EP, Centanni TM, Fink MK, Im KW,
Wilson LG, Kilgard MP. Neurobiolgy of Disease, 2015 (download file).
Vagus Nerve Stimulation
Delivered with Motor Training Enhances Recovery of Function after Traumatic
Brain Injury. Pruitt DT, Schmid AN, Kim LJ, Abe CM,
Trieu JL, Choua C, Hays SA, Kilgard MP, Rennaker RL. J Neurotrauma,
2015.
Speech training alters
consonant and vowel responses in multiple auditory cortex fields. Engineer
CT, Rahebi KC, Buell EP, Fink MK, Kilgard MP. Behavioral Brain Research, 287:256-64, 2015.
Pairing Speech Sounds With
Vagus Nerve Stimulation Drives Stimulus-specific Cortical Plasticity.
Engineer CT, Engineer ND, Riley JR, Seale JD, Kilgard MP. Brain Stimulation, 8:637-44, 2015.
Placebo-controlled vagus
nerve stimulation paired with tones in a patient with refractory tinnitus: a
case report. De Ridder D, Kilgard M, Engineer N, Vanneste S. Otology Neurotology,
36:575-80, 2015.
Activation of the
anti-inflammatory reflex blocks lipopolysaccharide-induced decrease in synaptic
inhibition in the temporal cortex of the rat. Garcia-Oscos
F, Peña D, Housini M, Cheng D, Lopez D, Cuevas-Olguin
R, Saderi N, Salgado Delgado R, Galindo Charles L,
Salgado Burgos H, Rose-John S, Flores G, Kilgard MP, Atzori M. J Neuroscience Research, 93:859-65,
2015.
Abnormal emotional learning
in a rat model of autism exposed to valproic acid in utero. Banerjee A,
Engineer CT, Sauls BL, Morales AA, Kilgard MP, Ploski JE. Front Behavioral Neuroscience, 8:387, 2014 (download
file).
Vagus nerve stimulation
during rehabilitative training improves functional recovery after intracerebral
hemorrhage. Hays SA, Khodaparast N, Hulsey DR, Ruiz A, Sloan AM, Rennaker
RL 2nd, Kilgard MP. Stroke,
45:3097-100. 2014 (download
file).
Speech
sound discrimination training improves auditory cortex responses in a rat model
of autism, Engineer CT, Centanni TM, Im KW, Kilgard MP. Front. Syst. Neurosci.
doi: 10.3389, 2014 (download
file).
Vagal nerve stimulation
blocks interleukin 6-dependent synaptic hyperexcitability
induced by lipopolysaccharide-induced acute stress in the rodent prefrontal
cortex. Garcia-Oscos F, Peña D, Housini M, Cheng
D, Lopez D, Borland MS, Salgado-Delgado R, Salgado H, D'Mello
S, Kilgard MP, Rose-John S, Atzori M. Brain
Behav Immun, 43:149-58,
2015.
Controlled-cortical impact
reduces volitional forelimb strength in rats. Pruitt D, Hays S, Schmid A, Choua C, Kim L, Trieu
J, Kilgard MP, Rennaker RL 2nd. Brain
Research, 1582:91-8, 2014.
Behavioral and neural
discrimination of speech sounds after moderate or intense noise exposure in
rats. Reed AC, Centannia TM, Borland MS, Matney
CJ, Engineer CT, Kilgard MP. Ear and
Hearing, 35:e248-61, 2014.
Speech sound processing
deficits and training-induced neural plasticity in rats with dyslexia gene
knockdown. Centanni TM, Chen F, Booker AM, Engineer CT, Sloan AM, Rennaker
RL, LoTurco JJ, Kilgard MP. PLoS One. 9(5):e98439, 2014 (download
file).
The timing and amount of
vagus nerve stimulation during rehabilitative training affect poststroke recovery of forelimb strength. Hays SA,
Khodaparast N, Ruiz A, Sloan AM, Hulsey DR, Rennaker RL 2nd, Kilgard MP. Neuroreport.
25:676-82, 2014 (download
file).
Environmental acoustic
enrichment promotes recovery from developmentally degraded auditory cortical
processing. Zhu X, Wang F, Hu H, Sun X, Kilgard MP, Merzenich MM, Zhou X. Journal of Neuroscience, 34:5406-15,
2014 (download
file).
Degraded
speech sound processing in a rat model of fragile X syndrome. Engineer CT,
Centanni TM, Im KW, Rahebi KC, Buell EP, Kilgard MP, Brain Research, 1564:72-84, 2014 (download
file).
Degraded auditory processing
in a rat model of autism limits the speech representation in non-primary
auditory cortex. Engineer CT, Centanni TM, Im KW, Borland MS, Moreno NA,
Carraway RS, Wilson LG, Kilgard MP. Dev Neurobiol. 74:972-86, 2014 (download
file).
Vagus Nerve Stimulation Delivered
During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke,
Khodaparast N, Hays SA, Sloan AM, Fayyaza T, Hulsey
DR, Rennaker RL II, Kilgard MP. Neurorehabilitation
and Neural Repair 28:698-706, 2014 (download
file).
Speech
training alters tone frequency tuning in rat primary auditory cortex,
Engineer CT, Perez CA, Carraway RS, Chang KQ, Roland JL, Kilgard MP. Behavioural Brain Research 258: 166–178, 2014 (download
file).
Detection and Identification
of Speech Sounds Using Cortical Activity Patterns, Centanni TM, Sloan AS,
Reed AC, Engineer CT, Rennaker RL, Kilgard MP, Neuroscience, 258:292-306, 2013 (download
file).
Safety and Efficacy of Vagus
Nerve Stimulation Paired With Tones for the Treatment of Tinnitus: A Case
Series. De Ridder D, Vanneste S, Engineer ND, Kilgard MP. Neuromodulation. 2013 Nov 20. (download
file)
Similarity of Cortical
Activity Patterns Predicts generalization Behavior. Engineer CT, Perez CA,
Carraway RS, Chang KQ, Roland JL, Sloan AM, Kilgard MP. PLoS One. 8(10),
2013.
Increasing diversity of
neural responses to speech sounds across the central auditory pathway.
Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP. Neuroscience. 252:80-97, 2013.
Vagus nerve stimulation
during rehabilitative training improves forelimb strength following ischemic
stroke. Khodaparast N, Hays SA, Sloan AM, Hulsey DR, Ruiz A, Pantoja M,
Rennaker RL, Kilgard MP. Neurobiology of
Disease, 60:80-88, 2013. (download
file)
Cortical speech-evoked response
patterns in multiple auditory fields are correlated with behavioral
discrimination ability. Centanni TM, Engineer CT, Kilgard MP. J Neurophysiol.
110:177-89, 2013. (download
file)
Knockdown of the
dyslexia-associated gene KIAA0319 impairs temporal responses to speech stimuli
in rat primary auditory cortex, Centanni TM, Booker AB, Sloan AM, Chen F,
Maher BJ, Carraway RS, Khodaparast N, Rennaker RL, LoTurco
JJ, Kilgard MP, Cerebral Cortex, Epub Feb 8, 2013. (download
file)
The bradykinesia assessment
task: an automated method to measure forelimb speed in rodents, Hays SA,
Khodaparast N, Sloan AM, Fayyaz T, Hulsey DR, Ruiz AD, Pantoja M, Kilgard MP,
Rennaker RL, Journal of Neuroscience
Methods, 214:52-61, 2013. (download file)
Impairment of cortical
GABAergic synaptic transmission in an environmental rat model of autism,
Banerjee A, García-Oscos F, Hall S, Roychowdhury S,
Galindo LC, Kilgard MP, Atzori M, Journal
of Neuropsychopharmacology, 16(6):1309-18, 2013.
(download file)
Three-Dimensional Flexible
Electronics Enabled by Shape Memory Polymer Substrates for Responsive Neural
Interfaces. Ware T, Simon D, Hearon K, Liu C,
Shah S, Reeder J, Khodaparast N, Kilgard MP, Maitland DJ, Rennaker RL 2nd, Voit
WE. Macromol Mater Eng. 297:1193-1202, 2012.
Directing
Neural Plasticity to Understand and Treat Tinnitus, Engineer ND, Møller AR, Kilgard MP, Hearing
Research, 295:58-66, 2013.
Harnessing
Plasticity to Understand Learning and Treat Disease, Kilgard MP, Trends in Neuroscience 35:715-22, 2012.
(download file)
(download
supplement)
The isometric pull task: a novel
automated method for quantifying forelimb force generation in rats, Hays
SA, Khodaparast N, Sloan AM, Hulsey DR, Pantoja M, Ruiz AD, Kilgard MP,
Rennaker RL, Journal of Neuroscience
Methods, 212:329-337, 2012. (download file)
Speech
discrimination after early exposure to pulsed-noise or speech, Ranasinghe
KG, Carraway RS, Borland MS, Moreno NA, Hanacik EA, Miller RS, Kilgard MP, Hearing Research, 289:1-12, 2012. (download
file)
Neural Mechanisms Supporting
Robust Discrimination of Spectrally and Temporally Degraded Speech,
Ranasinghe KG, Vrana WA, Matney CJ, Kilgard MP, J Assoc Res Otolaryngol
(epub). (download file)
Different Time Scales for
the Neural Coding of Consonant and Vowel Sounds, Perez CA, Engineer CT,
Jakkamsetti V, Carraway RS, Perry MS, Kilgard MP, Cerebral Cortex, 2012 (epub). (download file)
Inverted-U Function Relating
Cortical Plasticity and Task Difficulty. Engineer ND, Engineer CT, Reed AC,
Pandya PK, Jakkamsetti V, Moucha R, Kilgard MP, Neuroscience 205:81-90, 2012. (download
file)
Reorganization in Processing
of Spectral and Temporal Input in the Rat Posterior Auditory Field induced by
Environmental Enrichment. Jakkamsetti V, Chang KQ, Kilgard MP, Journal of Neurophysiology 107:1457-75,
2012. (download
file)
Pairing tone trains with
vagus nerve stimulation induces temporal plasticity in auditory cortex.
Shetake J, Engineer ND, Vrana WA, Wolf JT, Kilgard MP, Experimental Neurology, 233:342-9, 2012. (download file)
Repeatedly
pairing vagus nerve stimulation with a movement reorganizes primary motor
cortex. Porter BA, Khodaparast N, Fayyaz T, Cheung RJ, Ahmed SS, Vrana WA,
Rennaker RL 2nd, Kilgard MP, Cerebral
Cortex, 22:2365-74, 2012. (download file)
Cortical activity patterns
predict robust speech discrimination ability in noise. Shetake JA, Wolf JT,
Cheung RJ, Engineer CT, Ram SK, Kilgard
MP, European Journal of Neuroscience,
34:1823-38, 2011. (download file)
Vagus nerve stimulation
modulates cortical synchrony and excitability through the activation of
muscarinic receptors. Nichols J, Nichols AR, Smirnakis
S, Engineer ND, Kilgard MP, Atzori M, Neuroscience,
189:207-14, 2011. (download file)
Cortical map plasticity improves
learning but is not necessary for improved performance, Reed A, Riley J,
Carraway R, Carrasco A, Perez C, Jakkamsetti V, Kilgard MP, Neuron, 14;70:121-31, 2011. (download file)
(supplementary
information) (Press
Coverage)
Reversing pathological
neural activity using targeted plasticity, Engineer ND, Riley JR, Seale JD,
Vrana WA, Shetake JA, Sudanagunta SP, Borland MS,
Kilgard MP, Nature, 470:101-4, 2011.
(download
file) (supplementary
information) (Press
Coverage)
Discrimination of brief
speech sounds is impaired in rats with auditory cortex lesions, Porter BA,
Rosenthal TR, Ranasinghe KG, Kilgard MP. Behavioural Brain Research, 219:68-74, 2011. (download file)
Effects of damage to
auditory cortex on the discrimination of speech sounds by rats. Floody OR, Ouda L, Porter BA,
Kilgard MP. Physiology and Behavior, 101:260-268,
2010. (download file)
Effect of the environment on
the dendritic morphology of the rat auditory cortex. Bose M, Roychowdhury
S, Muñoz P, Nichols J, Jakkamsetti V, Porter B, Salgado H, Kilgard MP, Aboitiz
F, Dagnino-Subiabre A, Atzori M. Synapse, 64:97-110, 2010. (download file)
Chronic Stress Induces
Dendritic Atrophy in the Rat Medial Geniculate Nucleus: Effects on Auditory
Conditioning, Dagnino-Subiabre
A, Muñoz-Llancao P, Terreros
G, Wyneken U, Díaz-Véliz G,
Porter B, Kilgard MP, Atzori M, Aboitiz F, Behavioral
Brain Research, 203:88-96, 2009. (download file)
Cortical
Activity Patterns Predict Speech Discrimination Ability, Engineer CT, Perez
CA, Chen YH, Carraway RS, Reed AC,
Shetake JA, Jakkamsetti V, Chang KQ, Kilgard MP. Nature
Neuroscience, 11: 603-608, 2008 (download
file, supplemental
data, and video).
Sensory
Experience Determines Enrichment-Induced Plasticity in Rat Auditory Cortex,
Percaccio CR, Pruette AL, Mistry
ST, Chen YH, Kilgard MP. Brain Research,
1174:76-91, 2007 (download
file).
Differential
Reductions in Acoustic Startle Document the Discrimination of Speech Sounds in
Rats. Floody OR, Kilgard MP. Journal of the Acoustical Society of America, 122:1884-7, 2007 (download file).
Spectral
and Temporal Processing in Rat Posterior Auditory Cortex. PK Pandya, DL Rathbun, R
Plasticity
in the Rat Posterior Auditory Field following Nucleus Basalis Stimulation.
Puckett AC, Pandya PK, Moucha R, Dai W, Kilgard MP. Journal of Neurophysiology. 98:253-65, 2007. (download file)
Experience
Dependent Plasticity Alters Cortical Synchronization. Kilgard MP, Vazquez
JL, Engineer ND, Pandya PK. Hearing
Research. 229:171-179, 2007. (download
file)
Environmental
Enrichment Selectively Increases Glutamatergic Responses in Layer II/III of the
Auditory Cortex of the Rat. Nichols JA, Jakkamsetti V, Dinh
L, Kilgard MP, Atzori M. Neuroscience,
145: 832-840, 2007. (download
file)
Anesthesia
suppresses nonsynchronous responses to repetitive broadband stimuli.
Rennaker RL, Carey HL, Anderson SE, Sloan AM, Kilgard MP. Neuroscience,
145:357-69, 2007. (download file)
Neuroscientific Principles Underlying
Reorganization After Brain Injury. Percaccio CR, Kilgard MP, Brain Injury Professional, 3: 26-29,
2006. (download file)
Response
to Broadband Repetitive Stimuli in Auditory Cortex of the Unanesthetized
Rat. SE Anderson, MP Kilgard, AM Sloan, RL Rennaker, Hearing Research, 213:107-17, 2006 (download
file).
Cortical
Map Reorganization Without Cholinergic Modulation. Kilgard MP. Neuron. 48:529-30, 2005.
Environmental
Enrichment Increases Paired Pulse Depression in Rat Auditory Cortex. CR
Percaccio, ND Engineer, AL Pruette, PK Pandya, R Moucha, DL Rathbun, MP Kilgard, Journal of Neurophysiology, 94:3590-600, 2005 (download file).
Asynchronous
Inputs Alter Excitability, Spike Timing, & Topography in Primary Auditory
Cortex. PK Pandya, R
Background
Sounds Contribute to Spectrotemporal Plasticity In
Primary Auditory Cortex. R Moucha, PK
Environmental
Enrichment Improves Response Strength, Threshold, Selectivity, and Latency of
Auditory Cortex Neurons. Engineer ND, Percaccio CR, Pandya PK, Moucha R, Rathbun DL, Kilgard MP. Journal
of Neurophysiology, 92(1):73-82, 2004
(download file).
Cholinergic
Modulation of Skill Learning and Plasticity, M.P. Kilgard, Neuron, 38(678-680), 2003.
Cortical
Network Reorganization Guided by Sensory Input Features, M.P. Kilgard, P.K.
Pandya, N.D. Engineer, R. Moucha, Biological
Cybernetics, 87(5-6):333-43, 2002 (download
file).
Order Sensitive Plasticity in Adult Primary Auditory Cortex, M.P. Kilgard, M.M. Merzenich, Proceedings of the National Academy of Sciences, 99: 3205-3209, 2002 (download file).
Dynamic categories, M.P. Kilgard, Nature, 412:693-694, 2001. (download
file)
Spatial
Features Control Temporal Plasticity in Auditory Cortex, M.P. Kilgard, P.K.
Pandya, J.L. Vazquez, D. Rathbun, N.D. Engineer, R. Moucha,
Audiology and Neuro-otology, 6:196-202, 2001. (download file)
Sensory
Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex,
M.P. Kilgard, P.K. Pandya, J.L. Vazquez, Gehi, A.,
C.E. Schreiner, M.M. Merzenich, Journal of Neurophysiology, 86: 339-353,
2001. (download
file)
Distributed
Representation of Spectral and Temporal Information in Rat Auditory Cortex,
M.P. Kilgard, M.M. Merzenich, Hearing Research, 134(1-2): 16-28, 1999. (download
file)
Plasticity
of Temporal Information Processing in the Primary Auditory Cortex, M.P.
Kilgard, M.M. Merzenich, Nature Neuroscience, 1(8): 727-731, 1998. (download
file)
Nucleus
Basalis Activity Enables Cortical Map Reorganization, M.P. Kilgard, M.M.
Merzenich, Science 279(5357): 1714-1718, 1998. (download file)
Representations in Natural and Artificial Systems, P. Konig,
E. Bizzi, N. Burgess, N. Franceschini,
M.P. Kilgard, M. Oram, G, Sagerer,
C. Scheier, Zeitschrift
für Naturforschung,
53(7-8):738-51, 1998. (download file)
Sound-Induced
Seizures in Serotonin 5-HT2c Receptor Mutant Mice, T.J. Brennan, W.W.
Seeley, M.P. Kilgard, C.E. Schreiner and L.H. Tecott,
Nature Genetics, 16(4): 387-390, 1997. (download file)
Caenorhabditis elegans
rab-3 Mutant Synapses Exhibit Impaired Function and Are Partially Depleted of
Vesicles, M.L. Nonet, J.E. Staunton, M.P. Kilgard, T. Fergestad,
E. Jorgestad, E. Hartwig,
H.R. Horvitz, B.J. Meyer, J. Neuroscience, Nov 1;17(21):8061-8073, 1997.
(download
file)
Anticipated
Stimuli Across the Skin, M.P. Kilgard, M.M. Merzenich, Nature, V373,
Feb 23, p663, 1995.
Recessive Rab3 Mutations, M.P. Kilgard, M.L. Nonet, B.J. Meyer, Worm
Breeders Gazette, 13(1), p39, 1993.
Patents
(7):
System
for stimulating brain plasticity. M.P. Kilgard, M.M. Merzenich, United
States Patent 6,221,908, 1998.
Computer-Implemented
Methods and Apparatus for Alleviating Abnormal Behaviors. M.P. Kilgard,
M.M. Merzenich,
S. Bao, United States Patent 7,024,398, 2006.
Timing Control for Paired Plasticity, M.P. Kilgard, L.C. Cauller,
N.D. Engineer, C. McIntyre, W. Rosellini, United States Patent 8,489,185, 2013.
System,
Methods and Devices for Treating Tinnitus, United States Patent
Application, M.P. Kilgard, N.D. Engineer, Pierce DM, United States Patent
8,666,501, 2014.
Methods,
Systems, and Devices for Pairing Vagus Nerve Stimulation with Motor Therapy in
Stroke Patients, M.P. Kilgard, N.D. Engineer, Pierce DM, Rennaker RL,
United States Patent 8,700,145, 2014.
Systems,
Methods And Devices For Paired Plasticity, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United
States Patent 9,089,707, 2015.
Systems,
Methods And Devices For Treating Tinnitus, M.P. Kilgard, L.C. Cauller, N.D. Engineer, C. McIntyre, W. Rosellini, United
States Patent 8,934,967, 2015.
Methods for Enhancing Exposure Therapy Using Vagus Nerve
Stimulation, C.M. Rodriguez, M.P.
Kilgard, N.D. Engineer, United States Patent Application 13/095570.
Methods, Systems, and Devices
for Treating Tinnitus with VNS Pairing, M.P. Kilgard, N.D. Engineer, Pierce
DM. United States Patent Application 20,100,004,705.
Systems and Methods for Optimizing Targeted
Neuroplasticity, United States Patent Application 62/333,982.
Methods and Systems for Therapy of Multiple
Sclerosis, M.P. Kilgard, R.L. Rennaker, United States Patent Application 20160144176
2017 - UTSW Basic Neuroscience Series, Dallas,
Texas, “Directing Neural Plasticity to Understand and Treat Neurological
Disease”
2016 - DARPA Targeted Neuroplasticity Training
Kick-Off Meeting, San Diego, California, “Targeted
Neuroplasticity Training to Accelerate Complex Skill Learning”
2016 - Neuromodulation: The Science, San Francisco,
California, “Directing Neural Plasticity to Understand and Treat Neurological
Disease”
2016 - DARPA Targeted Neuroplasticity Training
Proposer’s Day Meeting, Arlington, Virginia, “Targeted Neuroplasticity: Science and Medical Applications”
2016 - Neuromuscular Plasticity Symposium,
University of Florida, Gainesville, Florida, “Directing Neural Plasticity to
Understand and Treat Neurological Disease”
2016 - DARPA Demo Day Meeting, Pentagon Courtyard,
Arlington, Virginia, “Treating Brain Damage”
2015 - Sensory Motor Performance Program Seminar,
Rehabilitation Institute of Chicago, Illinois, “Directing Neural Plasticity to
Understand and Treat Neurological Disease”
2015 - Neuroscience Seminar, University of Illinois,
Champaign, Illinois, “Directing Cortical Plasticity to Understand and Treat
Neurological Disease”
2015 - DARPA ElectRx
Meeting, Park City, Utah, “Directing
Neural Plasticity to Treat Neurological and Psychiatric Disease”
2015 - Neural Control of Movement, Charleston, South
Carolina, “Directing Neural Plasticity to Treat
Stroke and Other Neurological Diseases”
2014 - Neuroscience and Cognitive Science Seminar,
University of Maryland, College Park, Maryland, “Directing Cortical Plasticity
to Understand and Treat Neurological Disease”
2014 - Neuroscience Research Institute, University
of Manchester, Manchester, United Kingdom, “Directing Neural Plasticity to
Treat Stroke and Other Neurological Disorders”
2014 - National Institute on Deafness and other
Communication Disorders, Bethesda, Maryland, “Directing Cortical Plasticity to
Understand and Treat Neurological Disease”
2014 - 41st Neural Interfaces
Conferences, Dallas, Texas, “Directing Cortical Plasticity to Understand and
Treat Neurological Disease”
2014 - Macro to Micro: The Role of Spike Timing
Dependent Plasticity and Neural Hypersynchrony in
Disease Symposium, Association for Research in Otolarygology,
San Diego, California, “Directing Cortical Plasticity to Understand and Treat
Tinnitus”
2013 - Arnold Starr Lecture,
University of California, Irvine, “Directing Cortical Plasticity to Understand
and Treat Auditory Processing Disorders”
2013 - Neuroscience Program
Retreat, University of Southern California, Lake Arrowhead, California,
“Directing Neural Plasticity to Understand and Treat Neurological Disease”
2013 - IEEE Medical Device Symposium,
Richardson, Texas, “Targeting Neural Plasticity to Treat Neurological Disease”
2013 - Neurology
Grand Rounds, University of California, Irvine, “Targeting Neural
Plasticity to Treat Neurological Disease”
2013 - Auditory Plasticity and Aging Workshop,
National Institute for Ageing, Bethesda, Maryland, “Directing Plasticity to
Treat Neurological Disease”
2013 - University of North Carolina Neuroscience
Center Seminar Series, Chapel Hill, North
Carolina, “Directed Neural Plasticity as a Research Tool and a Clinical
Therapy”
2013 - Emotional Disorders and Their
Neural Correlates, University of
Wurzburg, Rödelsee, Germany, “Directed Neural Plasticity as a Research Tool and
a Clinical Therapy”
2013 - Neurosurgery Grand Rounds,
University of Texas Southwestern Medical Center, Dallas, Texas, “Directed
Neural Plasticity as a Research Tool and a Clinical Therapy”
2012 - American College of Neuropsychopharmacology meeting in
Hollywood, Florida, “Directing Neural Plasticity to Understand and Treat
Neurological Disease”
2012 - Neuroscience Institute seminar series at the University of Tennessee
Health Science Center, Memphis, “Directing Neural Plasticity to Understand and
Treat Neurological Disease”
2012 - Bridging the Gap Symposium, School of
Occupational Therapy, Texas Woman’s University, Denton, Texas, “Directing
Neural Plasticity to Treat Neurological Disease”
2012 - Neuroscience Institute seminar series at the University of
Tennessee Health Science Center, Memphis, “Directing Neural Plasticity to
Understand and Treat Neurological Disease”
2012 - Society for
Neuroscience satellite symposium: Rat Models of Autism: New
Insights from Novel Tools, New Orleans, “Speech sound processing
impairments in FMR1 knockout rats”
2012 - Tinnitus: the art and science of innovation, Tinnitus Research Initiative Meeting, Bruges
Belgium, “Optimizing
VNS-Directed Neural Plasticity for the Treatment of Chronic Tinnitus”
2012 - University of North Texas
Health Science Center Department of Pharmacology and Neuroscience seminar
series, “Directing Cortical Plasticity to Understand and Treat
Neurological Disease”
2011 - Mahoney Institute for Neurological Sciences
seminar series at the University of Pennsylvania, “Directing Cortical
Plasticity to Understand and Treat Neurological Disease”
2011 - Redwood Center for Theoretical Neuroscience seminar
series at the University of California at Berkeley, “Directing
Cortical Plasticity to Understand and Treat Neurological Disease”
2011 - Learning to Hear:
The Influence of Experience and Training on Auditory Skill Conference at the
Hugh Knowles Center of Northwestern University, “Directing Neural Plasticity to
Understand and Treat Speech and Hearing Disorders”
2011 - Entertainment Software applied to Cognitive Neurotherapeutics Society
Meeting, University of California at San Francisco, “Directing
Cortical Plasticity to Understand and Treat Neurological Disease”
2011 - Tinnitus Research Initiative Meeting, Buffalo,
New York, “Directing Cortical Plasticity to Understand and Treat Tinnitus”
2011 - Center for Neuroscience
Seminar Series at the University of Pittsburgh, “Directing Cortical
Plasticity to Understand and Treat Neurological Disease”
2011 - Winter Conference on the Neurobiology of Learning and
Memory, Park City, Utah, “Cortical map plasticity improves learning
but is not necessary for improved performance”
2010
– Crystal Charity Ball Autism Project, Dallas, Texas, “Speech Sound Processing
in Autism”
2010 – University of Texas at Arlington Seminar in Bioengineering,
Arlington, Texas, “New Tools to Rewire the Human Brain and Treat Neurological
Disease”
2010 - Tinnitus Research Initiative Meeting, Dallas,
Texas, “Reversing Pathological Neural Plasticity to Treat Tinnitus”
2009 - NIDCD Workshop: Brain
Stimulation for Treatment of Tinnitus, Bethesda, Maryland, “Using vagus
nerve stimulation to direct plasticity for the treatment of tinnitus”.
2009 - International Conference on Auditory Cortex,
Magdeburg, Germany, “Neural Coding and Plasticity in the Auditory System: From
Tones to Speech”.
2009 - University of
California at San Francisco Neuroscience Seminar, “Neural Coding and Plasticity
in the Auditory System: From Tones to Speech”.
2009 - University of
Michigan, Biology and Experience as Mediators of Neurodevelopmental Health
Seminar Series, “Sensory Experience and Cortical Plasticity”.
2009 - University of California at Los Angeles Neuroscience
Seminar, “Neural Coding and Plasticity in the Auditory System: From
Tones to Speech”.
2008 - Advances and
Perspectives in Auditory Neurophysiology, Washington D.C., “Speech Sound
Categorization and Plasticity in the Central Auditory System”.
2008 - University of Texas at Austin Neurobiology Seminar,
Austin, Texas, “Neural Coding and Plasticity in the Auditory System: From Tones
to Speech”.
2008 - Pediatric Academic Societies Meeting, Honolulu,
Hawaii, “Neural Plasticity in Animal Models”.
2008 - Healthy Minds
Conference, Sarasota, Florida, “Neural Processing of Speech Sounds”.
2008 - Linking Auditory
Neurophysiology to Perception Workshop, Computational and Systems
Neuroscience, Snow Bird, Utah, “Cortical Activity Patterns Predict
Speech Discrimination Ability”.
2008 - Real-Time Processing and the
Processing of Time Workshop, Computational and Systems
Neuroscience, Snow Bird, Utah, “Effect of Neural Correlations on
Speech Discrimination”.
2007 - University of Texas at Houston
Department of Neurobiology and Anatomy, Houston, Texas, “Neural
Coding and Plasticity in the Auditory System: From Tones to Speech”
2007 - Advances and Perspectives in
Auditory Neurophysiology, San Diego, California, “Activity Patterns in
Awake Auditory Cortex Predict Speech Discrimination Ability in Rats”
2005 - UCSF Keck Center
for Integrative Neuroscience, San Francisco, California, “Cortical Plasticity:
from Tones to Speech”
2005 - Center for
BrainHealth Symposia Reprogramming the Human Brain, Dallas, Texas, “Translating
Plasticity Research into Clinical Practice”
2005 - Krieger
Mind/Brain Institute at Johns Hopkins University, Baltimore, Maryland, “Perceptual Learning and
Cortical Self-organization”
2004 - Federation for
European Neuroscience conference- “Plasticity in Central Auditory Processing:
From Neural Mechanisms to Behavioral Significance”, Lisbon, Portugal, “Sensory
Experience and Cortical Plasticity”.
2003 - Neural Representation
and Processing of Temporal Patterns, Banbury
Conference, Cold Spring Harbor Laboratory, New York, “Sensory Experience and
Temporal Plasticity”
2003 - McDonnell Project
in Philosophy and the Neurosciences, Heron Island, Australia, “Sensory
Experience and Cortical Plasticity”
2003 - Association for Research in Otolaryngology, Daytona Beach,
Florida, “Perceptual learning and cortical self-organization”
2003 - American Academy
of Audiology, San Antonio, Texas, Perceptual Learning & Plasticity
Preconference (Co-presenter Beverly Wright, Northwestern University)
2003 - 21st Century
Science Initiative, Tarrytown, New York, “Sensory Experience and Cortical
Plasticity”
2003 - UTD/UTSW
Reprogramming the Human Brain Symposium, Dallas, Texas, “Targeted Manipulation
of Neural Plasticity”
2002 - University of Pennsylvania Johnson
Foundation for Molecular Biophysics, Department of Biochemistry and Biophysics,
and Department of Neuroscience, Philadelphia, Pennsylvania, “Sensory Experience
and Cortical Plasticity”
2001 - UT Southwestern Department of
Psychiatry and Center for Basic Neuroscience Seminar Series, Dallas,
Texas, “How Experience Shapes Brain Function”
2001 - Auditory Function
and Dysfunction:Molecular
and Physiological Mechanisms, Auckland, New Zealand, "Sensory Experience
and Cortical Plasticity"
2001 - American
Association for the Advancement of Science, San Francisco, "How Experience
Rewires the Brain"
2000 - Summer Brain
Institute, Doubletreee Hotel Dallas, "How is the
Brain like a Child? - a Neuroscience Perspective on Learning"
2000 - NICE2000: Neural
Plasticity and Learning, Grindelwald, Switzerland,
“Toward a General Theory of Cortical Plasticity”
1998 - Weizmann
Institute, Rehovot, Israel, "Stimulation of the Nucleus Basalis Enables
Plasticity of Spatial and Temporal Representations in Primary Auditory
Cortex"
1998 - Max Planck
Institute for Brain Research, Frankfurt, Germany, " Stimulation of the
Nucleus Basalis Enables Plasticity of Spatial and Temporal Representations in
Primary Auditory Cortex"
2001-present
– Faculty Advisor for the Eugene McDermott Scholars Program.
1999-present – UTD
Graduate Courses - Cellular Neuroscience, Developmental Neuroscience,
Information Processing in the Auditory Cortex, Cortical Plasticity,
Neural Basis of Speech Sound
Processing, and Matlab for Brain Sciences.
1999-present – UTD
Undergraduate Courses - Cellular Neuroscience,
Developmental Neuroscience, Behavioral Neuroscience, Auditory Neuroscience, and
Cortical Plasticity
2013 – Invited lecturer on biomedical
engineering, Erik Jonsson School of Engineering & Computer Science, UTD.
2000 – UT Southwestern Medical Center,
Psychiatric Genetics guest lecture “Toward a General Theory of Cortical
Plasticity”.
1996-1998 – Invited lecturer on
cortical plasticity, City College of San Francisco.
1994 – Teaching assistant,
Neuroscience for Pharmacists, UC San Francisco.
1994-1998 – Volunteer neuroscience
instruction for high school, middle school, and elementary schools throughout
the San Francisco Unified School District.
2016 – American Tinnitus Association Webinar, “Retuning the Tinnitus
Brain”
2016 – Vocational Nurses Association, Caring Society Lunch and Learn,
“Healing the Human Brain: The Next Medical Revolution”, Dallas Texas.
2013 – Innovations
in Neuro Technology… From Hearing to Strokes, Dallas Texas.
2012 – Summer Intensive
Auditory Rehabilitation Conference, Richardson, Texas, “New Brain-Based
Therapies for Auditory Problems”
2011 – Texas Instruments
Alumni Association and UT Dallas Retiree Association, Richardson, Texas,
“Helping the Brain Heal Itself”
2010 – Bodies the Exhibition, Dallas, Texas, “The
Brain: An Owner’s Guide”
2009 – The Brain: An
Owner’s Guide, Center for BrainHealth, Dallas, Texas, “New Tools for Brain
Repair”
2001 - Learning Brain
Expo (keynote speaker), San Antonio, Texas, "Learning and Brain
Plasticity"
1999 - Alief Independent School District, Houston, "How is
the Brain like a Child? - a Neuroscience Perspective on Learning"
Representational
Plasticity of Marmoset and Human Vocalizations in Rat Auditory Cortex. P.K.
Pandya, N.D. Engineer, R.
Moucha, W. Dai, D. L. Rathbun, A. Puckett, J. L. Vazquez,
Cherie R. Percaccio, M.P. Kilgard,
Association for Research in Otolaryngology, Florida, 2002.
Auditory
Enrichment Enhances Evoked Potential Amplitude in Rat Auditory Cortex
C. R. Percaccio, N.D.
Engineer, N. C. Dempsey, P.K.
Pandya, M.P. Kilgard, Association for Research in
Otolaryngology, Florida, 2002.
Characterization of Response
Properties in Rat Posterior Auditory Cortex D. L. Rathbun, N.D.
Engineer, R. Moucha, P.K.
Pandya, M.P. Kilgard,
Association for Research in Otolaryngology, Florida, 2002.
Auditory experience improves response
characteristics in rat primary auditory cortex neurons, N.D. Engineer, J.
Vasquez, P.K. Pandya, R. Moucha, D. Rathbun, M.P. Kilgard, Society for Neuroscience. San Diego, 2001.
Cortical Synchronization changed by
Experience-Dependent Plasticity in Rat A1, J.L. Vazquez, P.K. Pandya, N.D.
Engineer, R. Moucha, D. Rathbun, M.P. Kilgard, Society for Neuroscience. San Diego, 2001.
Background Stimuli Contribute to
Cortical Plasticity in Rat Primary Auditory Cortex, Moucha R, Pandya PK,
Vazquez J, Engineer ND, Rathbun D, Kilgard MP, Society for Neuroscience. San Diego, 2001.
Enriched auditory experience increases
selectivity, threshold and response strength of rat primary auditory cortex
neurons, N.D. Engineer, J. L. Vazquez, P.K. Pandya, R. Moucha, D.
Rathbun, M.P. Kilgard, Association for Research in Otolaryngology, Florida,
2001.
Parametric changes in the cross correlation strength in rat primary
auditory cortex as a function of experience, J. L. Vazquez, P.K. Pandya,
D. Rathbun, R. Moucha, N.D. Engineer, M.P. Kilgard, Association for Research in
Otolaryngology, Florida, 2001.
Plasticity of spectrotemporal coding in primary
auditory cortex enabled by cholinergic modulation, R. Moucha, P.K. Pandya, J.L.
Vazquez, D. Rathbun, N.D. Engineer, M.P. Kilgard, Association for Research in
Otolaryngology, Florida, 2001.
Frequency tuning plasticity in rat primary auditory cortex, P.K.
Pandya, J. Vazquez, D. Rathbun, N.D. Engineer, R. Moucha, M.P. Kilgard,
Association for Research in Otolaryngology, Florida, 2000.
Order Selective Plasticity in Primary Auditory Cortex, M.P. Kilgard, M.M.
Merzenich, Association for Research in Otolaryngology, Florida, 1999.
Plasticity of Temporal Information Processing in the Primary Auditory
Cortex, M.P. Kilgard, M.M. Merzenich, Society for Neuroscience, Washington
D.C., 1998.
Cholinergic Forebrain Mechanism in Cortical Map Reorganization, M.P.
Kilgard, M.M. Merzenich, Society for Neuroscience, Washington D.C., 1996.
Audiogenic
Seizures in 5-HT2c Receptor Mutant Mice, T.J. Brennan, M. Kilgard and L.H. Tecott, Society for Neuroscience, Washington D.C., 1996.