Sensory Transcriptomics
Characterizing the transcriptional basis of sensory tissue
Project mission
What is the transcriptional calling card of somatosensory and orofacial sensory tissues with respect to other tissues in humans ? Which regulators drive such a distinctive program ? How does somatosensory versus orofacial sensory transcriptional signals differ ? What are the fundamental cell types in these sensory tissues ? How do such transcriptional signatures affect the proteome ? What kind of plasticity occurs in diseases like chronic pain or migraine ? How do such changes affect the interactome ? Can we identify potential therapeutic targets from assays that provide high throughput snapshots of the transcriptomic landscape in healthy and diseased sensory tissues ? How conserved are such transcriptional landscapes with respect to other primates or with respect to rodent models ? Which regulatory links may be affected by evolutionary turnover and how does such turnover affect downstream molecular behavior and function ?
We use classic computational genomics as well as novel machine learning and artifical intelligence based approaches to answer such questions.