pradipta ray

Sensory Transcriptomics

Characterizing the transcriptional basis of sensory tissue

Project mission

What is the transcriptional calling card of somatosensory and orofacial sensory tissues with respect to other tissues in humans ? Which regulators drive such a distinctive program ? How does somatosensory versus orofacial sensory transcriptional signals differ ? What are the fundamental cell types in these sensory tissues ? How do such transcriptional signatures affect the proteome ? What kind of plasticity occurs in diseases like chronic pain or migraine ? How do such changes affect the interactome ? Can we identify potential therapeutic targets from assays that provide high throughput snapshots of the transcriptomic landscape in healthy and diseased sensory tissues ? How conserved are such transcriptional landscapes with respect to other primates or with respect to rodent models ? Which regulatory links may be affected by evolutionary turnover and how does such turnover affect downstream molecular behavior and function ?

We use classic computational genomics as well as novel machine learning and artifical intelligence based approaches to answer such questions.

Comparative transcriptome profiling of the human and mouse dorsal root ganglia: An RNA-seq-based resource for pain and sensory neuroscience research

Download the datasets, code for calculating sample statistics and copyright permission here.
Read the preprint.
Browse the dataset on the Pain Neurobiology Research Group website.
Understand the larger context of this project by looking at the spectrum of research performed at the Pain Neurobiology Research Group, led by Ted Price and Greg Dussor.