Types of plots of pharmacological data:


  1. dose-response a. standard units, both axes b. log units, dose axis c. log units (or some multiplier x), response axis d. log units, both axes
  2. receptor binding plots a. [bound] vs. [applied] € [B]/[L] € saturation plot (nonlinear) b. [bound]/[free] vs. [bound] €[B/F]/[B] € Scatchard plot € slope = -1/ KD € x intercept = Bmax c. % bound vs. log [inhibitor] € B % / [log I] € inhibitor plot d. ([bound0] - [bound])/[bound] vs. log [inhibitor] €([B0] - [B])/[B][log I] € Hill plot € slope = Hill coefficient e. bound (B) vs. time (t) € association plot f. bound (B) vs. time (t) € dissociation plot

kinetics

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Last updated Sep 3, 1998, 5:45 a.m.