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research > publications
For a comprehensive list of publications, please see my Google scholar account. For archival copies of high impact or relevant publications, theses and preprints, see below.
RNA Profiling of Neuropathic Pain-Associated Human DRGs Reveal Sex-differences in Neuro-immune Interactions Promoting Pain. Brain, in press, 2022
(first author)
Transcriptomic Analysis of Human Sensory Neurons in Painful Diabetic Neuropathy Reveals Inflammation and Neuronal Loss. Scientific Reports, 2022
Spatial transcriptomics reveals unique molecular fingerprints of human nociceptors. Science Transl Medicine, 2022
RNA sequencing on muscle biopsy from a 5-week bedrest study reveals the effect of exercise and potential interactions with dorsal root ganglion neurons. Physiological Reports, in press, 2022
Intercellular Arc signaling regulates vasodilation. J Neurosci, 2021
Diversity of receptor expression in central and peripheral mouse neurons estimated from single cell RNA sequencing. Neuroscience, 2021
Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank. PLoS Genetics, 2021
A pharmacological interactome platform for discovery of pain mechanisms and targets. Science Signalling, 2021
(co-corresponding author)
Review
Studying human nociceptors: from fundamentals to the clinic. Brain, 2021
A peptide encoded within a 5' untranslated region promotes pain sensitization in mice. PAIN, 2021
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits. Theranostics, 2021
A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist. Journal of Pain, 2021
Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice. Biological Psychiatry, 2020
The cellular basis of protease-activated receptor 2 - evoked mechanical and affective pain. JCI Insight, 2020
ACE2 and SCARF expression in human DRG nociceptors: implications for SARS-CoV-2 virus neurological effects. PAIN, 2020
A pharmacological interactome between COVID-19 patient samples and human sensory neurons reveals potential drivers of neurogenic pulmonary dysfunction. Brain, Behavior and Immunity, 2020
(first & co-corresponding author)
Pharmacological target-focused transcriptomic analysis of native versus cultured human and mouse dorsal root ganglia. PAIN, 2020
(corresponding author)
A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies. Diabetes, 2019
Review
Recent advances toward understanding the mysteries of the acute to chronic pain transition. Curr Opinion in Physiology, 2019
Differences between dorsal root and trigeminal ganglion nociceptors in mice revealed by translational profiling. J Neurosci, 2019
Transcriptome analysis of the human tibial nerve identifies sexually dimorphic expression of genes involved in pain, inflammation and neuro-immunity. Frontiers in Mol Neurosci, 2019
(first & corresponding author)
Electrophysiological and transcriptomic correlates of neuropathic pain in human primary sensory neurons. Brain, 2019
(co-first author)
Nociceptor translational profiling reveals the RagA-mTORC1 network as a critical generator of neuropathic pain. J Neurosci, 2019
Angiotensin II triggers peripheral macrophage-to-sensory neuron redox crosstalk to elicit pain. J Neurosci, 2018
Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq–based resource for pain and sensory neuroscience research. PAIN, 2018
(first author)
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice. ACS Chem Neurosci, 2017
DIRECTION: a machine learning framework for predicting and characterizing DNA methylation and hydroxymethylation in mammalian genomes. OUP Bioinfo, 2017
(co-first & co-corresponding author)
Group II mGluRs suppress hyperexcitability in mouse and human nociceptors. PAIN, 2016
Integrative analysis of haplotype-resolved epigenomes across human tissues. Nature, 2015
Integrative analysis of 111 reference human epigenomes. Nature, 2015
Distinct and predictive histone lysine acetylation patterns at promoters, enhancers, and gene bodies. G3: Genes | Genomes | Genetics, 2014
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell, 2013
Thesis
Computational Methods for Analyzing the Architecture and Evolution of the Regulatory Genome. PhD thesis, Carnegie Mellon, 2012-13
(thesis author)
DISCOVER: a feature-based discriminative method for motif search in complex genomes. OUP Bioinfo, 2009
(co-first author)
CSMET: comparative genomic motif detection via multi-resolution phylogenetic shadowing. PLoS CompBio, 2008
(co-first author)
Baycis: a bayesian hierarchical hmm for cis-regulatory module decoding in metazoan genomes. ReCoMB Proceedings: LNBI, 2008
(co-first author)
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